I was watching a recent Joe Rogan podcast where he was interviewing a person who had a background in pharmaceuticals, nutrition, diet, obesity, diabetes and food.  There was a segment in the talk where they discussed metabolic disease and its relationship to cancer and early onset diabetes in young adults.  This sparked my curiosity and once again I went down that rabbit hole of research and investigation into — what is metabolic disease? — how is metabolic disease related to cancer and other chronic illness?  The following are links to some of my findings?

Warburg effect — Oncology

In oncology, the Warburg effect is the observation that most cancer use aerobic glycolysis for energy generation rather than the mechanisms used by non-cancerous cells. This observation was first published by Otto Heinrich Warburg, who was awarded the 1931 Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme". Wikipedia

Encyclopedia Britannica:  metabolic disease; pathology

PubMed:  Abstract - Is Cancer a Metabolic Disease?

PubMed:  Abstract - Cancer as a metabolic disease

PubMed:  Abstract - Cancer as a Metabolic Disorder

National Library of Medicine:  Glucose Metabolism in Cancer: The Warburg Effect and Beyond

PubMed:  Abstract - Metabolic Pathways of the Warburg Effect in Health and Disease: Perspectives of Choice, Chain or Chance

Sep 3, 2024 The Hungry for Change Podcast

Think cancer is unbeatable? Think again. Meet Professor Thomas Seyfried, the biologist who's rewriting the rules with groundbreaking metabolic therapies. With a Ph.D. from the University of Illinois and postdoctoral research at Yale, Professor Seyfried is leading a revolution in how we fight diseases like cancer and epilepsy through diets like keto. At Boston College, he’s not just teaching— he’s challenging everything we thought we knew about these diseases. Author of 'Cancer as a Metabolic Disease,' his work is flipping the script on conventional medicine. Ready to uncover the truth about beating cancer? Watch now!

Dec 28, 2020

You can watch Dr. Thomas Seyfried's full interview for free by signing up here: https://mailchi.mp/metabolichealthsum... Dr. Thomas Seyfried is a Cancer Biology Researcher, Boston College Professor, and Author of the book "Cancer as a Metabolic Disease." In this clip, Dr. Seyfried walks us through the history of cancer as a metabolic disease. The story began in the early 1990s when a scientist named Otto Warburg defined the nature of cancer as a disease of mitochondrial function and energy metabolism. Dr. Seyfried and colleagues expanded on this concept by discovering that cancer cells could also thrive by using the amino acid glutamine as fuel, an important missing link in Warburg's central argument, according to Dr. Seyfried. In the full video, Dr. Seyfried eloquently explains how we think that ketogenic metabolic therapies work in cancer, including how they are being studied for the potential ability to sensitize cancer cells to the standard of care treatments. He also describes the complementary role of hyperbaric oxygen therapy (HBOT) and ketogenic therapies in cancer treatment research. Lastly, Dr. Seyfried describes the experiments that support Warburg's concept, and his evolving understanding of this complex disease. He also discusses the history of cancer as a genetic disease, why he introduced the "Glucose-Ketone Index" as a novel potential tool to monitor ketogenic treatments, and so much more.  Watch now!